Association of HMG-CoA reductase gene polymorphism with levels of lipids / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 207-210, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-248458
ABSTRACT
<p><b>OBJECTIVE</b>To study the distribution of ScrF1 restriction polymorphism in intron 2 of the 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase gene in Chinese Han population and the association of the polymorphism with coronary heart disease(CHD).</p><p><b>METHODS</b>HMG-CoA reductase genotyping was performed using polymerase chain reaction-restriction fragment polymorphism.</p><p><b>RESULTS</b>HMG-CoA reductase allelic frequencies of A, a were 0.519, 0.481; 0.440, 0.560 in CHD group and control group respectively. There was no significant difference in frequencies of allele and genotype in ScrF1 polymorphism between CHD group and control group(P>0.05). However, the levels of plasma very low density lipoprotein (VLDL) and TG in CHD patients with AA genotype were higher than those in CHD patients with other genotypes(P<0.05). The frequencies of A, a alleles at ScrF1 polymorphic site were significantly different from those reported in European Caucasians (0.44 vs 0.55, 0.56 vs 0.45, P<0.05).</p><p><b>CONCLUSION</b>No direct association was found between the ScrF1 polymorphism and CHD, but there is a significant correlation between the AA genotype of the HMG-CoA reductase gene and the levels of plasma VLDL and TG in CHD group.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Triglicerídeos
/
Sangue
/
Análise Química do Sangue
/
VLDL-Colesterol
/
Predisposição Genética para Doença
/
Hidroximetilglutaril-CoA-Redutases NADP-Dependentes
/
Povo Asiático
/
Metabolismo dos Lipídeos
/
Genética
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2003
Tipo de documento:
Artigo
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