Effects of monofluorphosphate and alphaD3 on the bone mineral density of mandibular of ovariectomy rats / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of monofluorphosphate and alphaD3 on the bone mineral density of mandibular of ovariectomy rats.</p><p><b>METHODS</b>39 female Sprague-Dawley rats about 90 days of age were randomly divided into the following treatment groups and treated for 12 weeks SHAM group, OVX group, MFP group, MFP+alphaD3 group. Rats of MFP group received monofluorphosphate by gastric feeding. Rats of MFP+alphaD3 group received monofluorphosphate and alphatD3 by gastric feeding. The femur and the mandibles were collected for histomorphometry and bone mineral density measurement.</p><p><b>RESULTS</b>The bone area, bone thick, and bone mineral density of femur in the OVX group were significantly lower than those of other groups, while the trabecular separation of the OVX group was significantly higher than that of other groups. The bone mineral density of mandible was increased in OVX group and MFP+alphaD3 group compared with SHAM group.</p><p><b>CONCLUSION</b>Monofluorphosphate and alphaD3 can obviously increase the mass of mandible. The bone mineral density of femur decreased after ovariectomy while it increased in mandibular.</p>