Expression and significance of hypoxia inducible factor-1alpha in buccal carcinoma / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the expression of hypoxia inducible factor-1alpha (HIF-1alpha) protein in buccal carcinoma and its biological significance.</p><p><b>METHODS</b>The expression of HIF-1alpha was assayed by means of immunohistochemical technique in 60 patients. The expression of HIF-1alpha and its relationship with clinical pathological factors and tumor prognosis were investigated and analyzed statistically by Kruskal-Wallis Test.</p><p><b>RESULTS</b>The positive rate of HIF-1alpha was higher in T3-4 than T1-2, and the positive rate of HIF-1alpha was higher in patients with cervical lymphatic metastasis than patients without cervical lymphatic metastasis. Patients with HIF-1alpha over-expression had poor prognosis than patients with HIF-1alpha lower expression.</p><p><b>CONCLUSION</b>Over-expression of HIF-1alpha is a vital biological marker in prognosis of buccal cancer.</p>