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Significant positive correlation of plasma BPDE-albumin adducts to urinary 1-hydroxypyrene in coke oven workers / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 179-183, 2007.
Artigo em Inglês | WPRIM | ID: wpr-249869
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the application of BPDE-albumin adducts as monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to explore possible relationship between BPDE-albumin adducts and urinary 1-hydroxypyrene (1-OHP) levels in them.</p><p><b>METHODS</b>Thirty-seven coke oven workers from a coke plant and 47 controls without the occupational exposure to PAHs were recruited in this study. The levels of plasma BPDE-albumin adducts and urinary 1-OHP were analyzed using high performance liquid chromatography.</p><p><b>RESULTS</b>The median levels of BPDE-albumin adducts (42.10 fmol/mg albumin) and urinary 1-OHP (5.46 micromol/mol creatinine) were significantly higher in coke oven workers than in controls (14.16 fmol/mg albumin, 2.96 micromol/mol creatinine, respectively; P<0.01). Multiple logistic regression analysis showed that coke oven workers were at higher risk of having BPDE-albumin adduct levels above 25.30 micromol/mg albumin (OR=1.79, P<0.01) and urinary 1-OHP levels above 4.13 micromol/mol creatinine (OR=2.45, P<0.05). There was a positive correlation between the levels of BPDE-albumin adducts and urinary 1-OHP in all subjects (rs=0.349, P<0.01).</p><p><b>CONCLUSION</b>BPDE-albumin adduct is a useful biomarker for monitoring long-term exposure to PAHs, and plasma BPDE-albumin adducts level is significantly correlated to urinary 1-OHP levels in coke oven workers.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Hidrocarbonetos Policíclicos Aromáticos / Pirenos / Urina / 7,8-Di-Hidro-7,8-Di-Hidroxibenzo(a)pireno 9,10-óxido / Albumina Sérica / Química / Monitoramento Ambiental / Exposição Ocupacional / Urinálise Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Hidrocarbonetos Policíclicos Aromáticos / Pirenos / Urina / 7,8-Di-Hidro-7,8-Di-Hidroxibenzo(a)pireno 9,10-óxido / Albumina Sérica / Química / Monitoramento Ambiental / Exposição Ocupacional / Urinálise Limite: Adulto / Humanos / Masculino Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2007 Tipo de documento: Artigo