Expression and role of augmenter of liver regeneration in patients with hepatic failure / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 217-220, 2009.
Article
em Zh
| WPRIM
| ID: wpr-250011
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression and role of augmenter of liver regeneration (ALR) in hepatic failure.</p><p><b>METHODS</b>ALR polyclonal antibody was prepared and purified. Serum ALR in patients with hepatic failure, chronic hepatitis B and healthy persons were quantified by ELISA, ALR mRNA in hepatic tissues were quantified by real-time PCR.</p><p><b>RESULTS</b>Different serum ALR levels foreshowed different outcomes for hepatic failure patients: The liver function was restored in 6 patients with higher ALR level [(1613.5+/-369.6) pmol/ml], and the liver function was deteriorated in 12 patients with lower ALR level [(462.3+/-235.8) pmol/ml]. ALR level in patients with chronic hepatitis B [(969.2+/-332.5) pmol/ml] was similar to that in healthy persons [(806.9+/-240.8) pmol/ml]. ALR mRNA level in hepatic failure patients receiving OLT (103.45 copies/microl) was lower than that in chronic hepatitis B patients (104.37 copies/microl) and healthy persons (104.31 copies/microl), ALR mRNA level in chronic hepatitis B and healthy persons was similar.</p><p><b>CONCLUSION</b>These findings suggest serum ALR level reflected ALR mRNA level in liver and is helpful in estimating the survival time of patients with hepatic failure.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
/
Prognóstico
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Sangue
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Proteínas Recombinantes
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RNA Mensageiro
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Ensaio de Imunoadsorção Enzimática
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Proteínas
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Estudos de Casos e Controles
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Expressão Gênica
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Reação em Cadeia da Polimerase
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Animals
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Female
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2009
Tipo de documento:
Article