Synthesis and antidepressant activities of aryl alkanol piperidine derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 324-329, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-250584
ABSTRACT
To explore novel monoamine reuptake inhibitor with antidepressant activity, a series of substituted aryl alkanol piperidine derivatives were designed and synthesized. All of them were new compounds, and their structures were confirmed with 1H NMR and HR-MS. The results showed that compounds 4, 5 and 8 displayed strong 5-HT, NA and DA reuptake inhibiting activities in vitro. Among the tested compounds, 4, 5 and 13 exhibited potent antidepressant activities in the mice forced swimming test. Compounds 4 and 5 have potent antidepressant activities and are worth further development.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Piperidinas
/
Relação Estrutura-Atividade
/
Natação
/
Sinaptossomos
/
Estrutura Molecular
/
Dopamina
/
Distribuição Aleatória
/
Serotonina
/
Norepinefrina
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo
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