Protective effect of extract of Apocynum venetum on kidneys of streptozotocin-induced diabetic rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 26-30, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-250625
ABSTRACT
The aim of this study is to investigate the effects and mechanism of extract of Apocynum venetum (AV) on kidneys of streptozotocin-induced diabetic rats. Diabetes mellitus (DM) was induced in rats by intraperitoneal injection of streptozotocin (STZ). The indexes of the blood glucose, renal function and oxidative stress were observed. The DM rats were administrated with the AV for 8 weeks, the above-mentioned indexes were detected. The blood glucose level, BUN, 24 h urine protein excretion, urine volume, renal index, renal cortex's MDA level in model groups all increased significantly. Renal cortex's SOD and GSH activities decreased significantly compared with the normal control group (P < 0.05). The above-mentioned indexes were significantly improved by the AV treatment (P < 0.05). AV have protective effects on renal function of kidneys of streptozotocin-induced diabetic rats, and maybe via inhibition of the renal oxidative stress.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Superóxido Dismutase
/
Sangue
/
Glicemia
/
Nitrogênio da Ureia Sanguínea
/
Medicamentos de Ervas Chinesas
/
Química
/
Ratos Wistar
/
Estresse Oxidativo
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo
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