Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 263-267, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-250632
ABSTRACT
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Química
/
Quinolonas
/
Inibidores de Integrase de HIV
/
Integrase de HIV
/
Concentração Inibidora 50
/
Metabolismo
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo
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