Advances in the study of HIV-1 integrase inhibitors of alpha, gamma-diketo compounds / 药学学报
Acta Pharmaceutica Sinica
; (12): 215-223, 2010.
Article
em Zh
| WPRIM
| ID: wpr-250639
Biblioteca responsável:
WPRO
ABSTRACT
HIV-1 integrase (IN) is an essential enzyme for retroviral replication. There is no analogue for this enzyme in human cells so that inhibition of IN will not bring strong effect on human body. Thus, HIV-1 IN has become a rational target for therapy of AIDS. This review provides a comprehensive report of alpha, gamma-diketo IN inhibitors discovered in recent years. Compilation of such data will prove to be beneficial in developing QSAR, pharmacophore hypothesis generation and validation, virtual screening and synthesis of compounds with higher activity.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Fisiologia
/
Estrutura Molecular
/
Química
/
HIV-1
/
Inibidores de Integrase de HIV
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Integrase de HIV
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Fármacos Anti-HIV
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Relação Quantitativa Estrutura-Atividade
/
Cetoácidos
Limite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Article