Development and validation of HPLC-UV-MS method for the control of four anti-diabetic drugs in suspected counterfeit products / 药学学报
Acta Pharmaceutica Sinica
;
(12): 347-352, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-250651
ABSTRACT
An HPLC-UV method has been developed for the determination of valibose, miglitol, voglibose and acarbose, the four anti-diabetic drugs. The separation was accomplished successfully by using reversed phase chromatography (Prevail carbohydrate column, 250 mm x 4.6 mm, 5 microm) with a gradient acetonitrile-phosphate buffer solution (pH 8.0) at a wavelength of 210 nm. Furthermore, the method of a high-performance liquid chromatography coupled with ESI-MS in positive ionization mode has been established. These two methods were successfully applied to the assay and qualitative detection of four alpha-glucosidase inhibitors in the potential counterfeit anti-diabetic drugs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espectrofotometria Ultravioleta
/
Química
/
Cromatografia Líquida de Alta Pressão
/
1-Desoxinojirimicina
/
Acarbose
/
Espectrometria de Massas por Ionização por Electrospray
/
Alfa-Glucosidases
/
Cromatografia de Fase Reversa
/
Inibidores de Glicosídeo Hidrolases
/
Hipoglicemiantes
Tipo de estudo:
Pesquisa qualitativa
Idioma:
Inglês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo
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