Pharmacokinetics of the alkaloids from the processed seeds of Strychnos nux-vomica in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 458-461, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-251061
ABSTRACT
<p><b>AIM</b>To study the pharmacokinetic process about the concentration in rat plasma of the alkaloids from processed seeds of Strychnos nux-vomica with RP-HPLC method.</p><p><b>METHODS</b>Hypersil BDS C18 column was used and the mobile phase consisted of acetonitrile-water at the flow rate of 0.8 mL.min-1. The UV detection wave length was 254 nm.</p><p><b>RESULTS</b>The concentration-time data of strychnine, brucine, strychnine N-oxide and brucine N-oxide were all in accordance with an open two-compartment model after i.v. alkaloids. Their parameters were as follows T1/2 alpha were (8 +/- 5), (4 +/- 3), (6.2 +/- 1.7) and (3.0 +/- 0.8) min, T1/2 beta were (262 +/- 125), (416 +/- 131), (285 +/- 50) and (342 +/- 141) min, CL were (17 +/- 4), (21 +/- 12), (1.9 +/- 1.8) and (2.8 +/- 1.1) mL.min-1, Vc were (1.4 +/- 0.5), (1.7 +/- 1.1), (0.24 +/- 0.16) and (0.23 +/- 0.06) L.kg-1, Vd were (6.0 +/- 1.2), (12 +/- 7), (0.8 +/- 0.6) and (1.5 +/- 0.6) L.kg-1, AUC were (57,578 +/- 25,578), (35,240 +/- 15,616), (93,088 +/- 22,375) and (177,712 +/- 120,110) h.microgram.L-1, respectively.</p><p><b>CONCLUSION</b>The method is a good reference for pharmacokinetics in human bodies.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Sementes
/
Estricnina
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Química
/
Tecnologia Farmacêutica
/
Ratos Sprague-Dawley
/
Óxidos N-Cíclicos
/
Strychnos nux-vomica
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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