Study on the pharmacokinetics of scutellarin in dogs / 药学学报

ABSTRACT

<p><b>AIM</b>To determine scutellarin in dog plasma and study the pharmacokinetics of scutellarin in the dog.</p><p><b>METHODS</b>Scutellarin in plasma of six dogs at different sampling time was determined after single dose of 120 mg i.v. by RP-HPLC. The mean plasma concentration-time curve was protracted and pharmacokinetic parameters were calculated.</p><p><b>RESULTS</b>The concentration-time curve of scutellarin can be fitted to a three-compartment model with the main pharmacokinetic parameters as follows T1/2 gamma, T1/2 alpha and T1/2 beta were (1.1 +/- 0.8) min, (7.0 +/- 2.8) min and (52 +/- 29) min, respectively, Vc was (880 +/- 508) mL, CL was (190 +/- 54) mL.min-1, AUC0-90 and AUC0-infinity were (574 +/- 134) mg.min.L-1 and (559 +/- 132) mg.min.L-1 respectively.</p><p><b>CONCLUSION</b>The concentration of scutellarin in plasma declined rapidly after single dose of 120 mg i.v. in dogs, and this suggested that the T1/2 of scutellarin should be taken into account in preparation exploitation and drug administration.</p>