Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol / 药学学报
Acta Pharmaceutica Sinica
;
(12): 260-263, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-251129
ABSTRACT
<p><b>AIM</b>To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.</p><p><b>METHODS</b>Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested.</p><p><b>RESULTS</b>Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis.</p><p><b>CONCLUSION</b>Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Enoxacino
/
Estrutura Molecular
/
Ciprofloxacina
/
Testes de Sensibilidade Microbiana
/
Norfloxacino
/
Química
/
Técnicas de Química Combinatória
/
Escherichia coli
/
Métodos
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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