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Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2956-2959, 2011.
Artigo em Chinês | WPRIM | ID: wpr-251250
ABSTRACT
<p><b>OBJECTIVE</b>To prepare paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD) loaded colon-specific release tablets.</p><p><b>METHOD</b>The core tablets were prepared with the mixture of Pae-beta-CYD inclusion complex, peotin and calcium acetate, and coated with ethanolic solution of Eudragit S100. The effects of coating weight, amount of plasticizer, curing time and temperature on the release of drug from tablets were investigated in vitro.</p><p><b>RESULT</b>About 5-6 h retarded release of paeonol in the dissolution media of pectinase or rats colon contents were obtained by 12% coating weight gain and 20% Dibutyl phthalate (DBP) was used as plasticizer, and subsequently curing the tablets at 45 degrees C for 12 h.</p><p><b>CONCLUSION</b>Pae-beta-CYD loaded colon-specific release tablets showed pH environment and enzyme dependant release properties.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acetofenonas / Comprimidos com Revestimento Entérico / Farmacocinética / Colite Ulcerativa / Química / Sistemas de Liberação de Medicamentos / Ratos Sprague-Dawley / Colo / Usos Terapêuticos / Beta-Ciclodextrinas Limite: Animais / Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Acetofenonas / Comprimidos com Revestimento Entérico / Farmacocinética / Colite Ulcerativa / Química / Sistemas de Liberação de Medicamentos / Ratos Sprague-Dawley / Colo / Usos Terapêuticos / Beta-Ciclodextrinas Limite: Animais / Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2011 Tipo de documento: Artigo