A Clinical and Histopathologic Study of Syringoma / 대한피부과학회지

ABSTRACT

BACKGROUND: Syringoma is a relatively common benign appendageal tumor derived from the intraepidermal eccrine ducts. It occurs predominantly in women at puberty or later in life. The lesions usually are multiple and may be present in great numbers. Histopathologically, numerous small ducts are embedded in a fibrous stroma and their walls are lined by two rows of epithelial cells. OBJECTIVE: The aim of this study is to investigate clinical and histopathologic features of syringoma in Koreans. METHODS: Total 32 patients were included in this study. Data complied were sex, age, onset of disease, symptoms, family history, localization, distribution, and some histopathologic findings including acanthosis, basal hyperpigmentation, proliferation of fibrous stroma, vacuolization of cells, keratin-filled cyst, and characteristic tad-pole appearance. RESULTS: 1. It was observed predominantly in females as the sex ratio of 311. The mean age at diagnosis was 37.5-years-old. 2. The age of onset was in the 2nd decade in 9 patients, 3rd decade in 10 patients, 4th decade in 7 patients, 5th decade in 5 patients, and 7th decade in 1 patient. 3. Only two patients complained of mild itching. 4. Family history was noted in 14 patients. 5. It occurred most frequently in the upper and lower eyelids(28 cases), and followed by forehead(5 cases), genitalia(3 cases), temple(2 cases), cheek(1 case), and neck(1 case). 6. The distribution was bilateral except two patients. 7. The color of lesion showed skin-colored(23 cases), yellowish(6 cases), and brownish (3 cases). 8. Twelve cases of acanthosis, 11 cases of basal hyperpigmentation, 26 cases of proliferation of fibrous stroma, 13 cases showing vacuolization of inner cell layer of ducts, 8 cases showing keratin-filled cysts and 15 cases showing characteristic tad-pole appearance were observed. CONCLUSION: According to our study, syringoma predominantly occurs in eyelids of women as bilateral asymptomatic skin-colored papules and histopathologic findings frequently shows keratin-filled cysts.