Design, synthesis and anti-platelet aggregation activities of ligustrazine-tetrahydroisoquinoline derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 326-331, 2015.
Article
em Zh
| WPRIM
| ID: wpr-251776
Biblioteca responsável:
WPRO
ABSTRACT
Abstract: Fifteen novel ligustrazine-tetrahydroisoquinoline derivatives were designed and synthesized according to the association principle of pharmaceutical chemistry. The structures were identified by IR, NMR and ESI-MS. The inhibitory activities of platelet aggregation induced by ADP and AA have been measured by Bron method. Preliminary pharmacological results showed that compounds 7g, 7h and 7n had potent inhibitory activity against platelet aggregation induced by AA, and the compound 7o showed significant inhibitory activity against platelet aggregation induced by ADP.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pirazinas
/
Inibidores da Agregação Plaquetária
/
Desenho de Fármacos
/
Química
/
Agregação Plaquetária
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Tetra-Hidroisoquinolinas
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Article