Design and synthesis of photoaffinity biotin labelled 2'-O-propargyl-guanosine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 59-63, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-251817
ABSTRACT
Photoaffinity labeling is widely applied to demonstrate targets of small molecule ligands. In this paper, biotin photoaffinity labeled molecule with propargyl group 1 has been designed and synthesized, followed it's labeling of N2-acetyl-2'-O-propargyl guanosine 9 by "click chemistry". This technology presents delight development potential in labeling of second messenger cyclic nucleotide, antisense oligonucleotide or siRNA.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Biotina
/
Química
/
Marcadores de Fotoafinidade
/
Química Click
/
Guanosina
/
Ligantes
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Artigo
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