Forecast on shelf life of Chinese Angelica based on its chemical components variation / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To predict the shelf life of Chinese Angelica by investigating the stability of its active components.</p><p><b>METHOD</b>The classic homeothermia method was used for forecast the shelf life, and HPLC was applied for quantitative determination of chemical compounds in Chinese Angelica.</p><p><b>RESULT</b>The correlation equations, thermal constant at ambient temperature (k(25 degrees C)) and shelf life (t(0.9)) for coniferyl ferulate and Z-Ligustilide were lgk = -5152. 1/T + 13.8 (r = 0.9985), 3. 33 x 10(-4), 13 d and lgk = -4064.6/T + 10.4 (r = 0.9997), 5.91 x 10(-4), 7 d, respectively.</p><p><b>CONCLUSION</b>The shelf life of Chinese Angelica has been established, which suggests that it is very important for ensuring the safety and efficacy of Chinese crude drug.</p>