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Optimization of enzymatic extraction of effective constituents from fibrous roots of Salvia miltiorrhiza by central composite design and response surface method / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1976-1981, 2008.
Artigo em Chinês | WPRIM | ID: wpr-252159
ABSTRACT
The fibrous roots are the residues of production of cut crude drug of Danshen (Salvia miltiorrhiza). Enzymatic pretreatment and ultrasonic extraction are beneficial to extract effective constituents from fibrous roots more effectively. The present research was to optimize the enzymatic parameters by the central composite design and response surface method. Under the best conditions, the yields of total tanshinones and total salvianolic acids in the extracts of enzymatic pretreatment increased by 113.92% and 30.64%, comparing with the non-enzymatic extraction, respectively. TLC analysis also showed that the types of effective constituents in the two samples were not affected by enzymatic hydrolysis. Meanwhile, the complex correlation coefficients of the mathematical models were high, which provided a good prediction.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenantrenos / Medicamentos de Ervas Chinesas / Química / Raízes de Plantas / Salvia miltiorrhiza / Abietanos Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenantrenos / Medicamentos de Ervas Chinesas / Química / Raízes de Plantas / Salvia miltiorrhiza / Abietanos Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2008 Tipo de documento: Artigo