Studies of betuionic acid on cell cycle and related protein expressions on mice of bearing H22 tumor cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1739-1743, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-252232
ABSTRACT
<p><b>OBJECTIVE</b>To study the betulonic acid on the cell cycle and related protein expressions on mice of bearing H22 tumor cells.</p><p><b>METHOD</b>Flow cytometray was used to observe the changes of betulonic acid on the cell cycle and P53 of H22 tumor cells. Immunohistochemistry was determined the espressions of PI3K and AKT.</p><p><b>RESULT</b>Increasing the doses of betulonic acid, the number of H22 cells in S phase and G2 phase was increasing gradually, it can speculate that when the betulonic acid act on cells, the cells were blocked in S and G2 phase and inhibited the protein expressions of PI3K and AKT.</p><p><b>CONCLUSION</b>Betulonic acid may be up-regulate the activity of P53 and inhibite the expressions of PI3K and AKT, so that it inhibited the survival pathway of tumor cells.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Imuno-Histoquímica
/
Ciclo Celular
/
Sobrevivência Celular
/
Química
/
Regulação da Expressão Gênica
/
Fase G2
/
Proteína Supressora de Tumor p53
/
Fosfatidilinositol 3-Quinases
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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