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Protective effects of compound shenhua tablet on diabetic nephropathy rats / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 352-355, 2012.
Artigo em Chinês | WPRIM | ID: wpr-252512
ABSTRACT
<p><b>OBJECTIVE</b>To observe the renal protection effects of Compound Shenhua Tablet (CST) on diabetic nephropathy (DN) rats.</p><p><b>METHODS</b>DN rats were given a normal diet for 9 months after they were induced by intraperitoneal injection of STZ at the dose of 65 mg/kg after uninephrectomized. They were randomly divided into 4 groups, i. e., the normal control group, the model control group, the CST group, and the Irbesartan group. The intervention was given by gastrogavage for 6 weeks. The general state, 24 h urine protein, urine micro-albumin (mAlb), serum creatinine (SCr), blood urea nitrogen (BUN), glucose (GLU), triglyceride (TG), total cholesterol (TC), total protein (TP), and albumin (ALB) levels were observed before and after intervention. Renal pathological changes were observed by PAS staining and transmission electron microscope.</p><p><b>RESULTS</b>After 6 weeks of drug intervention, when compared with the model control group, the general state was improved in the CST group and the Irbesartan group. The levels of 24 h urine protein, urine mAlb, SCr, BUN, GLU, TG, and TC were obviously lower in the CST group and the Irbesartan group than in the model group as well as in the same group before treatment (P<0.05, P<0.01). There was no statistical difference between the two treatment groups (P>0.05). The renal pathological changes and the renal ultrastructure were improved to some degree in the two groups when compared with those in the model control group.</p><p><b>CONCLUSIONS</b>CST could attenuate the renal damage of diabetes and delay renal deterioration process. Its effectiveness was equivalent to that of Irbesartan.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Medicamentos de Ervas Chinesas / Ratos Sprague-Dawley / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Tratamento Farmacológico / Rim / Fitoterapia Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Medicamentos de Ervas Chinesas / Ratos Sprague-Dawley / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Tratamento Farmacológico / Rim / Fitoterapia Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2012 Tipo de documento: Artigo