Mechanism of the influence of CCE3 on bone mineral element metabolism in ovariectomized rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 129-132, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-252690
ABSTRACT
<p><b>AIM</b>To investigate the influence of CCE3 on bone mineral element metabolism and relative hormone in ovariectomized rats.</p><p><b>METHODS</b>24 female SD rats were divided randomly into 4 groups (n = 6) (1) Normal control; (2) sham ovariectomy; (3) ovariectomy(OVX); (4) OVX + CCE3.</p><p><b>RESULTS</b>(1) Ca, Mg, S, Co, Mn, Zn reduced obviously and P increased in the bone of the OVX rats. (2) E2, P, TSH, T4, CT, cortisol, GH reduced obviously and IL-6, FSH, LH increased obviously in serum of the OVX rats. (3) CCE3 corrected the changes of Ca, Mg, S, Co, Mn, Zn and P in bone as well as the changes of E2, P, TSH, T4, CT, cortisol, GH and IL-6, FSH, LH in serum of the OVX rats.</p><p><b>CONCLUSION</b>Changes of relative hormone and IL-6 induced by CCE3 are the important mechanism of the influence of CCE3 on bone mineral element metabolism in ovariectomized rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoporose
/
Quinestrol
/
Sangue
/
Hormônio Luteinizante
/
Ovariectomia
/
Densidade Óssea
/
Interleucina-6
/
Ratos Sprague-Dawley
/
Usos Terapêuticos
/
Tratamento Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2009
Tipo de documento:
Artigo
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