The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 475-478, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-252736
ABSTRACT
<p><b>AIM</b>To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.</p><p><b>METHODS</b>SD rats were divided into three groups Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.</p><p><b>RESULTS</b>There was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.</p><p><b>CONCLUSION</b>Ang-(1-7) can relieve the renal process of diabetic rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fragmentos de Peptídeos
/
Farmacologia
/
Fator de Crescimento Derivado de Plaquetas
/
RNA Mensageiro
/
Angiotensina I
/
Ratos Sprague-Dawley
/
Diabetes Mellitus Experimental
/
Nefropatias Diabéticas
/
Fator de Crescimento Transformador beta1
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2008
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS