Mitochondrial function score combined with Gleason score for predicting the progression of prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 220-222, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-252828
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the mitochondrial function score in combination with Gleason score in predicting the progression of prostate cancer.</p><p><b>METHODS</b>This study included twenty 58-79 (70.1 +/- 1.2) years old patients with prostate cancer treated by radical prostatectomy. The epithelioglandular mitochondrial function scores of the patients were obtained under the transmission electron microscope and assessed according to Flameng grading. Meanwhile, their Gleason scores were analyzed and, based on the scores, the patients were divided into Groups I (Gleason score 2 -4) and II (Gleason score 5 -7).</p><p><b>RESULTS</b>The mitochondrial function score of Group I was significantly different from that of Group II (4.0 +/- 0.8 versus 2.3 +/- 0.6, P < 0.05), with a negative correlation with the Gleason score (r = -0.793, P < 0.05). One year follow-up showed a significantly lower mortality in Group I (0/8) than in Group II (6/12) (P < 0.05).</p><p><b>CONCLUSION</b>Mitochondrial dysfunction exists in prostate cancer patients, particularly in those with higher malignancy. The mitochondrial function score combined with Gleason score plays a valuable role in predicting the progression of prostate cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias da Próstata
/
Estudos Retrospectivos
/
Mitocôndrias
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS