HPLC-TOF-MS analysis of metabolites of Diffusa effective extracts in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1301-1304, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-252921
ABSTRACT
<p><b>OBJECTIVE</b>To analyze p-coumaril acid, trans-6-O-p-coumaroyl scandoside methyl ester and its metabolites in rat plasma after intragastric administration of exocarpium Diffusa effective extracts.</p><p><b>METHOD</b>Rat blood samples were collected 1.0 h after oral administration of 0.4 g x kg(-1) exocarpium Diffusa effective extracts, and then were analyzed by using HPLC-Q-TOF-MS.</p><p><b>RESULT</b>In rat plasma, only one metabolite was detected. The structure was identified by reference substance to be p-coumaril acid.</p><p><b>CONCLUSION</b>The methyl glucoside metabolite in rat from the main component parts of trans-6-O-p-coumaroyl scandoside methyl ester droppings of vines in Diffusa effective extracts is p-coumaril acid. This experiment provides a theortical basis for studying chemical compositions and pharmacodynamic action of Diffusa.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espectrometria de Massas
/
Medicamentos de Ervas Chinesas
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Ratos Sprague-Dawley
/
Hedyotis
/
Metabolismo
/
Métodos
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Artigo
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