Effects of atrial excitable period on the stability of atrial fibrillation in goats / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 992-994, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-253025
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of atrial excitable period (EP) on the stability of atrial fibrillation (AF) in goats.</p><p><b>METHODS</b>Ten female goats were instrumented with epicardial electrodes patches on the left atrium (LA) free wall. AF was induced and maintained by a home-made stimulator with frequency of 50 Hz at a 1-second duration and a 2-seconds interval. The stimulator was disconnected regularly. AF-induced duration, average AF cycle length (AFCL), and atrial effective refractory period during AF (ERP(AF)) were measured; EP was calculated by AFCL-ERP(AF).</p><p><b>RESULTS</b>Eight goats were studied. Persistent AF (> 24 h) could be induced in all the 8 goats within 6-16 days. When the induced AF lasted for 3-10 min or 24 h, the AFCL was 98.3 ms +/- 11.0 ms and 84.9 ms +/- 5.2 ms (P < 0.05), respectively, ERP(AF) was 90.5 ms +/- 13.2 ms and 63.0 ms +/- 4.8 ms (P < 0.05), respectively, and EP was 7.8 ms +/- 2.4 ms and 21.9 ms +/- 3.5 ms (P < 0.05), respectively.</p><p><b>CONCLUSION</b>The decrease in ERP(AF) is more significant than the shortening in AFCL, resulting in the gradually widening of EP which may contribute to the perpetuation of AF.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fibrilação Atrial
/
Cabras
/
Modelos Animais de Doenças
/
Eletrocardiografia
/
Átrios do Coração
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2005
Tipo de documento:
Artigo
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