Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation / 药学学报

ABSTRACT

<p><b>AIM</b>To search for compounds through structural modification of cyclovirobuxine D, using 20 or 21-aminosteroids as lead compound for the treatment of cerebrovascular diseases with better lipid peroxidation inhibitory activity.</p><p><b>METHODS</b>According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.</p><p><b>RESULTS</b>Four new compounds were obtained and confirmed by spectra.</p><p><b>CONCLUSION</b>Lipid peroxidation inhibitory effects of cyclovirobuxine D analogues were tested by using TBA method. Some compounds showed better activity than that of cyclovirobuxine D.</p>