Profile-effect on quality control of Houttuynia cordata injection / 药学学报

ABSTRACT

<p><b>AIM</b>To find corresponding relationship between the fingerprint of Houttuynia cordata injections from different factories and their effects.</p><p><b>METHODS</b>Houttuynia cordata injections from six different factories were determined by gas chromatography (GC) and gas chromatography-mass spectra (GC-MS), and GC fingerprints were classified by hierarchical clustering. The anti-inflammatory activity of Houttuynia cordata injections was characterized through the rat pleurisy model induced by carrageenin and the mice ear edema model by dimethylbenzene.</p><p><b>RESULTS</b>The anti-inflammatory effect of the injections from the first class factories on the two model was significant, while those from the second class not. GC-MS analysis result indicated that main effect compounds in Houttuynia cordata injections are methyl n-nonyl ketone, decanoylacetaldehyde, lauryl aldehyde, capryl aldehyde, beta-pinene, beta-linalool, 1-nonanol, 4-terpineol, alpha-terpineol, bornyl acetate, n-decanoic acid and acetic acid, geraniol ester etc.</p><p><b>CONCLUSION</b>There is corresponding relationship between the fingerprint of Houttuynia cordata injections and effect to a certain extent.</p>