In vitro and in vivo stability of 9-nitrocamptothecin lactone form in rats / 药学学报
Acta Pharmaceutica Sinica
; (12): 888-892, 2005.
Article
em Zh
| WPRIM
| ID: wpr-253547
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the in vitro and in vivo stability of 9-nitrocamptothecin lactone form in rat plasma.</p><p><b>METHODS</b>The specific and accurate HPLC method was developed for quantifying 9-nitrocamptothecin lactone form and the total lactone and carboxylate forms simultaneously. By using of this method, the ratios of lactone form to the total in rat plasma at different time were determined in vitro and in vivo. The results were compared to determine which was the main factor influencing the stability of 9-nitrocamptothecin lactone form in rat plasma in vivo.</p><p><b>RESULTS</b>The stability of lactone form in rat plasma was much higher in vivo than that in vitro.</p><p><b>CONCLUSION</b>Blood cells help to increase the stability of 9-nitrocamptothecin lactone form. Clearance from blood in vivo is the primary factor which influences the plasma stability of 9-nitrocamptothecin lactone form. The kinetic process of 9-nitrocamptothecin lactone form and total drug in rats were both best fitted to a two-compartment model. However, the process of 9-nitrocamptothecin carboxylate form in vivo was best fitted to a one-compartment model.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Sangue
/
Camptotecina
/
Farmacocinética
/
Ácidos Carboxílicos
/
Cromatografia Líquida de Alta Pressão
/
Ratos Sprague-Dawley
/
Área Sob a Curva
/
Estabilidade de Medicamentos
/
Lactonas
/
Métodos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Article