The influence of absorption enhancer and preparation of paclitaxel on its intestinal mucous membrane permeation detected by enhancement by using electron spin resonance technique / 药学学报
Acta Pharmaceutica Sinica
;
(12): 861-864, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-253552
ABSTRACT
<p><b>AIM</b>To investigate the permeation mechanism of paclitaxel by enhancers and preparation factors.</p><p><b>METHODS</b>The fluidity of mucous membrane and membrane protein conformation changes were determined by using electron spin resonance (ESR) when mucous membrane was treated by several enhancers. At the same time, the factors of penetration of lower dissolution drug across the intestinal mucous membrane were studied in three formulas inclusion complex, microemulsion and injection.</p><p><b>RESULTS</b>Polyethylene glycol (PEG) 1500, hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and phospholipid as enhancers could reinforce the permeation of paclitaxle because of loosening of protein conformation in intestinal mucous membrane. Paclitaxel-HP-beta-CD inclusion complex and paclitaxel microemulsion as vehicle could significantly increased permeation kinetic rate of paclitaxel with fluid diffuse method.</p><p><b>CONCLUSION</b>Characteristics of enhancing intestinal absorption of poor dissolution drug had been provided with enhancer the change of membrane fluid.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fosfolipídeos
/
Polietilenoglicóis
/
Veículos Farmacêuticos
/
Farmacocinética
/
Paclitaxel
/
Ratos Sprague-Dawley
/
Espectroscopia de Ressonância de Spin Eletrônica
/
Beta-Ciclodextrinas
/
Sinergismo Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Artigo
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