Isolation and identification of two new epimer from the mother liquid of megestrol acetate / 药学学报

ABSTRACT

<p><b>AIM</b>To study the impurity in the drug megestrol acetate.</p><p><b>METHODS</b>Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis.</p><p><b>RESULTS</b>Two new epimers were isolated from the mother liquid of the drug megestrol acetate.</p><p><b>CONCLUSION</b>These new epimers were identified as 17alpha-acetoxy-2beta,6alpha-dimethylprega-4-ene-3,20-dione (1) and 17alpha-acetoxy-2alpha,6alpha-dimethylprega-4-ene-3,20-dione (2).</p>