Genetic and epigenetic risks of intracytoplasmic sperm injection method / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 643-673, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-253777
ABSTRACT
Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection (ICSI) procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent that consequences of the genetic abnormalities underlying male subfertility (or infertility) and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aberrações dos Cromossomos Sexuais
/
Espermatogênese
/
Anormalidades Congênitas
/
Translocação Genética
/
Cromossomo X
/
Cariótipo XYY
/
Infecções por HIV
/
Risco
/
Aberrações Cromossômicas
/
Deleção Cromossômica
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Fatores de risco
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
/
Gravidez
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2006
Tipo de documento:
Artigo
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