The effect of epigenetic sperm abnormalities on early embryogenesis / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 131-142, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-253865
ABSTRACT
Sperm are a highly specialized cell type derived to deliver the paternal haploid genome to the oocyte. The epigenetic, or gene regulatory, properties and mechanisms of the sperm assist in preparation of the paternal genome to contribute to embryogenesis and the genome of the zygote. Many recent studies have addressed the issue of altered epigenetic processes in the sperm. This review evaluates the current understanding of DNA damage, chromosome aneuploidy, reduced telomere length, malformations of the centrosome, genomic imprinting errors, altered mRNA profiles, and abnormal nuclear packaging in the sperm prior to fertilization and the observed effects on embryogenesis. Attention has also been given to understanding the underlying etiology of sperm with altered epigenetic mechanisms in humans.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Espermatozoides
/
Anormalidades Congênitas
/
Dano ao DNA
/
RNA Mensageiro
/
Núcleo Celular
/
Telômero
/
Impressão Genômica
/
Centrossomo
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2006
Tipo de documento:
Artigo
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