Effects of TGF beta1 autocrine blockage on osteosarcoma cells / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 155-156, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-254001
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of transforming growth factor beta1 (TGFbeta1) autocrine blockage on proliferation activity and drug sensitivity of osteosarcoma. METHODS; Northern blot, MTT determination, and 3H thymidine incorporation were used to investigate the effects of antisense TGF beta1 gene on osteosarcoma.</p><p><b>RESULTS</b>The proliferation of osteosarcoma cells transfected by antisense TGF beta1 gene was suppressed markedly, and adriamycin sensitivity was significantly increased.</p><p><b>CONCLUSION</b>Blockage of osteosarcoma cells TGF beta1 autocrine loop inhibits cell proliferation and enhances chemotherapy sensitivity.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Neoplasias Ósseas
/
RNA Mensageiro
/
Transfecção
/
Doxorrubicina
/
Osteossarcoma
/
Divisão Celular
/
Elementos Antissenso (Genética)
/
Fator de Crescimento Transformador beta
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2004
Tipo de documento:
Artigo
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