Expression of PTEN and Caspase-3 and their clinicopathological significance in primary gastric malignant lymphoma / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 19-24, 2004.
Article
em En
| WPRIM
| ID: wpr-254034
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of PTEN and Caspase-3 in malignant lymphoma of the stomach and explore their role in progression of primary gastric malignant lymphoma.</p><p><b>METHODS</b>Formalin-fixed paraffin embedded tissues from 56 cases of primary gastric malignant lymphoma and their adjacent non-tumor mucosa were evaluated for PTEN and Caspase-3 protein expression by streptavidin-biotin-complex (SABC) immunohistochemistry. Their expression was compared with clinical tumor parameters with the relationship between PTEN and Caspase-3 expression concerned as well.</p><p><b>RESULTS</b>The positive rate of PTEN expression in primary gastric lymphomas (50.0%, 28/56) was significantly lower than that in adjacent non-tumor gastric mucosa (96.4%, 27/28) (P < 0.05). Meanwhile, 43 of 56 (76.8%) gastric lymphomas indicated Caspase-3 expression, less than that in adjacent non-tumor mucosa (93.5%, 29/31) (P < 0.05). The expression of PTEN was negatively correlated with invasion and lymph node metastasis of gastric lymphoma (P < 0.05), while the Caspase-3 expression was negatively associated with the latter one (P < 0.05). Additionally, the PTEN expression was positively correlated with Caspase-3 expression in the primary gastric malignant lymphoma (P < 0.05).</p><p><b>CONCLUSIONS</b>The down-regulated expression of PTEN and Caspase-3 played an important role in progression of primary malignant gastric lymphoma. PTEN, as a molecular marker of pathobiological behaviors of tumor, contributes to tumor progression by increasing cell mobility and angiogenesis, as well as decreasing cell adhesion and apoptosis.</p>
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Assunto principal:
Patologia
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Neoplasias Gástricas
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Biomarcadores Tumorais
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Regulação para Baixo
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Monoéster Fosfórico Hidrolases
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Caspases
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Proteínas Supressoras de Tumor
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PTEN Fosfo-Hidrolase
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Caspase 3
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Mucosa Gástrica
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2004
Tipo de documento:
Article