Comparative study of fibronectin gene expression in tissues from hypertrophic scars and diabetic foot ulcers / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 90-94, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-254047
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression characteristic of fibronectin gene in hypertrophic scars and diabetic ulcer tissues.</p><p><b>METHODS</b>The biopsies from normal skins, hypertrophic scars and diabetic foot ulcers were taken. The technique of quantitative polymerase chain reaction (PCR) was used to evaluate the gene expression of fibronectin in the above biopsies.</p><p><b>RESULTS</b>Fibronectin gene expression was enhanced in hypertophic scars and decreased in diabetic foot ulcers compared with that in normal skins. Quantitative comparison showed about 2-fold increase of fibronectin mRNA level in hypertrophic scars and about 3-fold decrease of fibronectin mRNA level in diabetic ulcers as compared with that in normal skins.</p><p><b>CONCLUSIONS</b>Fibronectin gene expression is influenced by the tissue environment. Different expression and synthesis of fibronectin may cause different outcomes in wound healing.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Expressão Gênica
/
Fibronectinas
/
Cicatriz Hipertrófica
/
Pé Diabético
/
Genética
/
Metabolismo
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2002
Tipo de documento:
Artigo
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