Study of serum level of cortisol and peripheral T lymphocyte subsets state in the hepatitis B virus carriers / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 330-332, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-254067
ABSTRACT
<p><b>OBJECTIVE</b>To study of serum level of cortisol and peripheral T lymphocyte subsets state in the hepatitis B virus (HBV) carriers.</p><p><b>METHODS</b>Sixty chronic HBV carriers and ten healthy controls were all enrolled in this present study. Serum expression of cortisol was determined by radioimmunoassay, and also flow cytometry was performed to evaluate peripheral blood T lymphocyte subset.</p><p><b>RESULTS</b>Compared with those in normal controls, the serous levels of cortisol in chronic HBV carriers were significantly elevated, while there was no distinct difference in the proportion of CD4+ T lymphocytes ( P > 0.05) with the decreased odds of CD4+/CD8+ lymphocytes( P < 0.05) and obvious higher proportion of CD8+ T lymphocytes( P < 0.05). In comparison between HBeAg positive group and HBeAg negative group, the serous levels of cortisol of the former group were significantly higher ( P < 0.05), and so proportion of CD8+ T was too ( P < 0.05). However, there is no significant differences in the proportion of CD4+ T lymphocyte ( P > 0.05).</p><p><b>CONCLUSION</b>The elevated serum cortisol and increased CD8+ T lymphocytes subsets in the chronic HBV carriers, suggested that there was disturbance of endocrine-immune response in the chronicity of HBV infection.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Virologia
/
Sangue
/
Hidrocortisona
/
Portador Sadio
/
Vírus da Hepatite B
/
Subpopulações de Linfócitos T
/
Alergia e Imunologia
/
Hepatite B
/
Metabolismo
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2008
Tipo de documento:
Artigo
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