Study on T cell subsets in HIV/AIDS patients / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>Analyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development.</p><p><b>METHODS</b>T cell subsets from 15 normal control subjects, 79 HIV/ AIDS patients were detected by FCM.</p><p><b>RESULTS</b>With diesase progression, CD4+ Naive cell counts and ratio was both decreased obviously (P < 0.001); CD4+ Tcm cell counts was significantly decreased (P < 0.001), CD4+ Tcm cell ratio was obviously higher (P = 0.002); CD4 TEM cell ratio was obviously increased( P < 0.001); CD8+ T Naive cell counts and ratio was also decreased obviously (P < 0.05); CD8+ T(CM), T(EM), T(EMRA) are not significantly different.</p><p><b>CONCLUSIONS</b>The peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.</p>