Application of serum hepatitis B virus large surface protein determination in lamivudine anti-viral therapy for patients with hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 133-135, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-254120
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlation between serum hepatitis B virus large surface protein (HBV-LP) and hepatitis B virus DNA (HBV-DNA) load in hepatitis B patients treated with lamivudine, and the application of serum HBV-LP measurement in evaluation of lamivudine therapeutic effect and end point judgement.</p><p><b>METHODS</b>HBV DNA was detected by fluorescent quantitative PCR (FQ-PCR), serum HBV-LP was detected by enzyme linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>Both HBV-DNA and HBV-LP decreased in patients responding to lamivudine therapy, and HBV-LP turned negative 3 months later than HBV-DNA. In patients resistant to lamivudine therapy, neither HBV-DNA nor HBV-LP turned negative. In patients whose symptoms relapsed, HBV-LP didn't turn negative, while HBV-DNA was undetectable only transitorily.</p><p><b>CONCLUSION</b>Measuring serum HBV-LP dynamically can be useful in evaluation of lamivudine therapeutic effect.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Virologia
/
Sangue
/
DNA Viral
/
Ensaio de Imunoadsorção Enzimática
/
Proteínas do Envelope Viral
/
Vírus da Hepatite B
/
Reação em Cadeia da Polimerase
/
Resultado do Tratamento
/
Lamivudina
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2008
Tipo de documento:
Artigo
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