Relativity analysis of chronic hepatitis B virus genotype and clinical pathology / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship between chronic hepatitis B virus genotypes and clinical pathology.</p><p><b>METHODS</b>HBV genotype was determined in 92 cases with chronic hepatitis B patients and the relationship between HBV genotypes and clinical, serological and histological data of the patients was analyzed.</p><p><b>RESULTS</b>Sixteen cases were infected with HBV genotype B (17.4%), 71 with genotype C (77.2%), 3 with HBV classified as genotype B+C (3.2%) and in 2 (2.2%) cases HBV genotype was not confirmed. ALT level and HBV DNA load log value were (82.6+/-82) U/L, (84.7+/-71.5) U/L and (5.8+/-1.4), (5.9+/-1.5) respectively in genotypes B and C patients, in 8 cases of genotype C group liver cirrhosis was diagnosed, but no statistical significance was seen.</p><p><b>CONCLUSION</b>No significant differences in clinical, serological or histological data were detected between genotypes B and C patients.</p>