Advances in pathogenesis and correlated clinical research of hypercoagulability in β thalassemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 774-778, 2014.
Article
em Zh
| WPRIM
| ID: wpr-254201
Biblioteca responsável:
WPRO
ABSTRACT
This article summarizes the pathogenesis of hypercoagulability in β thalassemia patients, including platelet activation, alteration of red blood cell membranes, abnormal expression of adhesion molecules on vascular endothelial cells and iron overload. Clinical evidence, clinical manifestations of hypercoagulable state and thrombosis in β thalassemia and the effect of splenectomy on hypercoagulable state were reviewed. Strategies to prevent and treat the thromboembolic events in β-thalassemia intermedia are also discussed, including transfusion therapy to raise hemoglobin levels, avoidance or delay of splenectomy and a number of treatments in the exploration.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Talassemia beta
/
Trombofilia
/
Agregação Eritrocítica
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2014
Tipo de documento:
Article