Pathogenesis of human metapneumovirus infection and research on attenuated live vaccine / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 548-554, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-254250
ABSTRACT
Numerous studies have indicated that human metapneumovirus (hMPV) is an important viral pathogen in acute respiratory infections in children, presenting similar manifestations with respiratory syncytial virus (RSV). HMPV infection peaks in the winter-spring season and is more prevalent in younger ages, especially in children less than 1 year old. Host innate immune response has been implicated in recognition of pathogen-associated molecular patterns (PAMPs) of the virus. This recognition occurs through host pattern recognition receptors (PRRs). Toll like receptors (TLRs) are one of the largest class of PRRs which initiate and regulate adaptive immune responses. Some studies have indicated that TLR 3 and TLR 4 may play critical roles in hMPV infection. Construction of recombinant mutant viruses lacking one or two N-linked glycosylation sites in the F protein by using site-directed mutagenesis and reverse genetics may be helpful for developing attenuated live vaccines.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vacinas Atenuadas
/
Vacinas Virais
/
Vacinas Sintéticas
/
Infecções por Paramyxoviridae
/
Metapneumovirus
/
Alergia e Imunologia
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2014
Tipo de documento:
Artigo
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