Clinical significance of expression of PSA, hK2, PSMA in the peripheral blood of patients with prostate cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 479-481, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-254289
ABSTRACT
<p><b>OBJECTIVE</b>To find sensitive and specific micro-metastic markers for prostate cancer.</p><p><b>METHODS</b>Using nested reverse transcription-PCR, we examined the expression of PSA, hK2 and PSMA mRNA in peripheral blood mononuclear cells of 51 patients with prostate cancer, 33 patients with benign prostate hyperplasia (BPH) and 32 normal young people.</p><p><b>RESULTS</b>The expression rates of PSA, hK2 and PSMA mRNA were 52.9%, 43.1% and 64.7%, respectively in prostate cancer group, and 6.2%, 7.7% and 4.6%, respectively in control group (BPH patients and normal young people) with statistical significance (P < 0.01). Although the expression rate of PSA and hK2 mRNA increased with cancer progression, there was no statistical significance among patients in different stages. The expression rate of PSMA mRNA was higher than that of PSA and hK2 mRNA in each clinical stage.</p><p><b>CONCLUSION</b>PSMA mRNA expression detected by nested RT-PCR is of greater value for the diagnosis, therapy choice and prognostic evaluation of prostate cancer patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Hiperplasia Prostática
/
Neoplasias da Próstata
/
Sangue
/
Biomarcadores Tumorais
/
Antígeno Prostático Específico
/
Calicreínas Teciduais
/
Glutamato Carboxipeptidase II
/
Invasividade Neoplásica
/
Estadiamento de Neoplasias
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2004
Tipo de documento:
Artigo
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