Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 287-289, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-254352
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and risk of breast cancer among women.</p><p><b>METHODS</b>Two hundred seventeen cases with breast cancer and 218 matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by PCR-RFLP methods. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression model.</p><p><b>RESULTS</b>We found that the frequency of the MTHFR C677TT genotype among cases was significantly different from that among controls (32.7% vs. 24.8%; P = 0.02). The MTHFR C677TT genotype had an increased risk of breast cancer compared with the 677CC genotype (95% CI, 1.09 - 3.14). No significant association between the MTHFR C677T or A1298C polymorphism and risk of the cancer was observed.</p><p><b>CONCLUSION</b>These findings suggest that 677CT polymorphism in MTHFR may be a genetic susceptibility factor for breast cancer among Chinese women.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
Neoplasias da Mama
/
China
/
Mutação Puntual
/
Predisposição Genética para Doença
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Povo Asiático
/
Frequência do Gene
/
Genética
/
Genótipo
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2004
Tipo de documento:
Artigo
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