Association study of bronchial asthma with polymorphisms of IL-4 and IL-4R receptor genes / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 97-100, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-254499
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of polymorphisms of IL-4 gene (rs2243250, rs2243283) and IL-4R gene (rs1805012, rs1801275, rs1805010) with susceptibility to asthma among ethnic Chinese in Qingdao.</p><p><b>METHODS</b>For 400 asthma patients and 200 healthy subjects, above polymorphisms were detected with SnaPshot method.</p><p><b>RESULTS</b>For rs1805012, the frequency of TC genotype in the asthma group was significantly lower than the control group (8.8% vs. 15.5%, χ (2)= 6.498, P= 0.039), and so were the frequencies of TC+ CC genotypes (9.0% vs. 15.5%, χ (2) = 5.522, P= 0.019) and the C allele (4.6% vs. 7.7%, χ (2) = 4.729, P= 0.039). No significant difference was detected between the two groups in the frequency of the remaining four polymorphisms or the haplotypes formed by rs2243250 and rs2243283 (All P> 0.05).</p><p><b>CONCLUSION</b>This study has indicated that rs1805012 polymorphism of IL-4R gene is associated with asthma in ethnic Han Chinese from Qingdao region. TC+ CC genotypes have a protective role against asthma compared with TT genotype. However, polymorphisms of IL-4 gene are not associated with susceptibility to asthma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Interleucina-4
/
Receptores de Interleucina-4
/
Predisposição Genética para Doença
/
Povo Asiático
/
Alelos
/
Genética
/
Genótipo
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2014
Tipo de documento:
Artigo
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