Protecting effect of human-derived neurotrophin-6 on retrogradely degenerated motoneurons of facial nucleus of rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 397-400, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-254649
ABSTRACT
<p><b>AIM</b>The protecting effect of human-derived neurotrophin-6 (NT-6) on injured neurons was investigated to test the neurobiological characteristics of human-derived NT-6.</p><p><b>METHODS</b>Adult SD rats were used and divided into two groups, normal control group and experiment group. The right facial nerve of the experimental rats was sectioned. The experimental animals were subdivided into three groups, blank control group, NT-6 group and saline control group. The rats were raised for two weeks. Brain stem of the rats was removed and transversely sliced. Nissle stain and ChAT immunohistochemical stain of the slices were carried out to observe the role of NT-6 in protecting facial motoneurons.</p><p><b>RESULTS</b>The number of the ChAT positive neurons and the intensity of Nissle stain in the facial nucleus of NT-6 group were significantly augmented compared with that of the blank and saline control groups.</p><p><b>CONCLUSION</b>The human-derived NT-6 could partially protect the facial motoneurons from retrograde degeneration induced by their axon damage.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Ratos Sprague-Dawley
/
Fármacos Neuroprotetores
/
Biologia Celular
/
Modelos Animais de Doenças
/
Nervo Facial
/
Neurônios Motores
/
Fatores de Crescimento Neural
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS