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Effects of electroacupuncture and simple acupuncture on changes of IL-1, IL-4, IL-6 and IL-10 in peripheral blood and joint fluid in patients with rheumatoid arthritis / 中国针灸
Chinese Acupuncture & Moxibustion ; (12): 840-844, 2010.
Artigo em Chinês | WPRIM | ID: wpr-254865
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of electroacupuncture on rheumatoid arthritis (RA).</p><p><b>METHODS</b>In a randomized and controlled trial, sixty-three cases with RA were randomly divided into an electroacupuncture group (n = 32) and a simple acupuncture group (n = 31). Baihui (GV 20), Fengchi (GB 20), Quchi (LI 11), Waiguan (TE 5), Guanyuan (CV 4) and Zusanli (ST 36) were selected by coordination method combined whole and local acupoints. The electroacupuncture group was treated with electroacupuncture at the local acupoints near painful joints, continuous wave, retaining needle for 30 minutes, and then electroacupuncture at Back-shu acupoints, retaining needle for 15 minutes, and the simple acupuncture group was treated with the same acupoints selection and acupuncture manipulation without electroacupuncture apparatus. They were all treated once every other day for 20 days as one course. After 3 courses, changes of interleukins in peripheral blood and joint fluid of patients were observed.</p><p><b>RESULTS</b>Both of electroacupuncture and simple acupuncture had significant effect on IL-1, IL-4, IL-6 and IL-10 in peripheral blood and joint fluid of patients with RA ( P < 0.01, P < 0.05). But after electroacupuncture, the absolute value and improvement value of decreasing IL-1 in peripheral blood and joint fluid were super than those of simple acupuncture (all P < 0.05), and of IL-4 in joint fluid was super than that after simple acupuncture (P < 0.05), and of IL-6 and the absolute value of decreasing IL-10 were almost the same after both treatment (all P > 0.05), and after electroacupuncture, the improvement value of IL-10 in peripheral blood and joint fluid were super than those after simple acupuncture (both P < 0.05).</p><p><b>CONCLUSION</b>Electroacupuncture can effectively decrease the proinflammatory cytokine of IL-1 and IL-6 and increase the inhibition cytokine of IL-4 and IL-10 and improve the internal environment of occurrence and progression of RA.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artrite Reumatoide / Líquido Sinovial / Terapêutica / Sangue / Terapia por Acupuntura / Eletroacupuntura / Interleucinas / Interleucina-4 / Interleucina-6 / Interleucina-1 Tipo de estudo: Ensaio Clínico Controlado Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Acupuncture & Moxibustion Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artrite Reumatoide / Líquido Sinovial / Terapêutica / Sangue / Terapia por Acupuntura / Eletroacupuntura / Interleucinas / Interleucina-4 / Interleucina-6 / Interleucina-1 Tipo de estudo: Ensaio Clínico Controlado Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Acupuncture & Moxibustion Ano de publicação: 2010 Tipo de documento: Artigo