Influence of gelatin particle size and gelatin/calcium phosphate cement ratio on repairing potency of composite artificial bone material / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 293-300, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-255196
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of gelatin particle (GP) size and gelatin/calcium phosphate cement (GP/CPC) ratio on repairing potency of comparison artificial bone material.</p><p><b>METHODS</b>Composite GP/CPC materials with different GP size (100~200 μm vs. 200~300 μm) and ratio(5% vs. 10%) were prepared. Physiochemical and biological properties, including porosity, resistance to compression, ultrastructure and biocompatibility were compared among 4 groups of GP/CPC materials. Different GP/CPC materials were used to repair the critical-size cranial bone defect in rabbit model, and the histology and newly formed bone inside scaffolds (nBIS) were examined and compared among different groups.</p><p><b>RESULTS</b>GP/CPC with GP of 200~300 μm possessed larger micropores than that with GP of 100~200 μm (P<0.05). The GP/CPC containing 10% GP had higher porosity than that containing 5% GP (P<0.05). The animal model study showed that more new bone formed in those defects filled with GP/CPC containing 10% GP with 200~300 μm in size compared with GP/CPC containing 5% GP with 100~200 μm in size (P<0.05). While GP/CPC containing 5% GP with 100~200 μm in size showed a higher level of resistance to compression.</p><p><b>CONCLUSION</b>Both the particle size of GP and its ratio in the GP/CPC affect the properties of the composite biomaterials and their role in bone repairing. In particular, the GP/CPC containing 10% GP with 200~300 μm in size is most suitable for repairing critical-size cranial bone defect in animal model.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Tamanho da Partícula
/
Materiais Biocompatíveis
/
Cimentos Ósseos
/
Fosfatos de Cálcio
/
Química
/
Porosidade
/
Alicerces Teciduais
/
Gelatina
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2015
Tipo de documento:
Artigo
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