Progress on interleukin-27 in tumor immunity / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 223-228, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-255207
ABSTRACT
As a member of IL-6/IL-12 cytokine family, IL-27 is a heterodimeric cytokine composed of the p28 and EBI3. Functioning as a linkage between innate and adaptive immunity, IL-27 is mainly produced by activated antigen-presenting cells and has a variety of responder cells including T cells, NK cells, macrophages and dendritic cells. IL-27 plays an antitumor role through promoting the production of cytotoxic T cells, regulating the differentiation of T cell subsets, enhancing the function of NK cells and inhibiting the angiogenesis. On the other hand, IL-27 may also have a positive effect on tumor progress and metastasis. IL-27 can be used as a reference marker for tumor diagnosis, due to its relation to the occurrence and development of tumors. This article reviews the research progress on the roles of IL-27 in tumor biological regulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Dendríticas
/
Células Matadoras Naturais
/
Linfócitos T Citotóxicos
/
Subpopulações de Linfócitos T
/
Alergia e Imunologia
/
Interleucina-27
/
Macrófagos
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2015
Tipo de documento:
Artigo
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