Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 211-216, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-255209
ABSTRACT
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-β, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Transdução de Sinais
/
Caderinas
/
Fator de Crescimento Transformador beta
/
MicroRNAs
/
Transição Epitelial-Mesenquimal
/
Via de Sinalização Wnt
/
Metástase Neoplásica
/
Recidiva Local de Neoplasia
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2015
Tipo de documento:
Artigo
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